About Rare Genetic Disorders of Obesity

Recent research has revealed genetic mechanisms that lead to rare disorders of obesity. In particular, studies suggest that several genetic defects affecting the melanocortin 4 (MC4) pathway—which serves a critical role in regulating appetite and weight—lead to intense feelings of hunger and to obesity.

Advances in genetic studies have identified several diseases that are the result of genetic defects affecting the MC4 pathway, most notably:

These MC4 pathway deficiencies can cause severe, early-onset obesity that is life-threatening.

Learn about the role of the MC4 pathway in genetic obesity >

This program is supported by Rhythm, a Boston-based biopharmaceutical company developing the MC4R peptide agonist, setmelanotide (RM-493), for obesity caused by genetic deficiencies in the MC4 pathway.
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